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Your Path to Cancer Prevention

Protect Your Future with Genetic Insights

Your DNA holds important cancer risk clues

Your DNA holds important cancer risk clues

People often carry genetic mutations known as cancer susceptibility genes, which increase their likelihood of developing certain cancers.

Over half of people

In the UK will be diagnosed with cancer.

5-10% of cancers

Are linked to a hereditary genetic variant.

Genetic variants

Increase your risk of developing cancer.

Your Path to Cancer Prevention

Protect Your Future with Genetic Insights

Your DNA holds important cancer risk clues

People often carry genetic mutations known as cancer susceptibility genes, which increase their likelihood of developing certain cancers.

Over half of people

In the UK will be diagnosed with cancer.

5-10% of cancers

Are linked to a hereditary genetic variant.

Genetic variants

Increase your risk of developing cancer.

Why genetic testing?

A simple test to identify genetic changes

Fast, non-invasive

How it works

Patient completes Requisition and Consent Form as well as Family History Questionnaire

Saliva Sample Kit sent to patient

Saliva Sample sent to local UK lab

Susceptibility Cancer Testing commences

Report sent to your Physician

Genetic Counselling if report positive for susceptibility genes

The process

Choose your test

There are multiple panels you can choose from depending on the type of cancer you have. Read more below to select the most appropriate one, or discuss with your doctor if unsure.

Personal details for personalised reporting

There are multiple panels you can choose from depending on the type of cancer you have. Read more below to select the most appropriate one, or discuss with your doctor if unsure.

Sample preparation & testing

Once all the paperwork is complete, we will send you a kit to insert your saliva sample; the kit has pre-paid postage for you to post at your convenience. Testing commences immediately when the lab receives your sample kit, and results will be ready in approximately 15 days.

Report & Consultation

Once your report is ready, your doctor will receive a copy, and so will you. If you are a carrier of any of the susceptibility genes, we will arrange for a genetic counsellor to contact you to discuss the implications and support you might require, as well as that of your family members. There is no additional cost for the genetic counsellor appointment.

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The presence of certain genetic mutations not only informs cancer susceptibility but also provides critical insights into disease progression, recurrence risk, and survival outcomes. Testing for these mutations can help personalise prognosis and direct treatment strategies, improving overall patient care.1,2,3,4,5,6,7

Yang D, Khan S, Sun Y, et al. Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer. JAMA. 2011;306(14):1557–1565. doi:10.1001/jama.2011.1456

The STRIPAK Complex Regulates the Hippo Kinase Cascade. Cancer Discov 1 February 2020; 10 (2): OF12. https://doi.org/10.1158/2159-8290.CD-RW2019-187

Antonis C. Antoniou, Ph.D., Silvia Casadei, Ph.D., Tuomas Heikkinen, Ph.D., et. al. Breast-Cancer Risk in Families with Mutations in PALB2.N Engl J Med 2014;371:497-506.DOI:10.1056/NEJMoa1400382.VOL.371 NO.6

Southey MC, Goldgar DE, Winqvist R, Pylkäs K, et al. PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. J Med Genet. 2016 Dec;53(12):800-811. doi: 10.1136/jmedgenet-2016-103839. Epub 2016 Sep 5. PMID: 27595995; PMCID: PMC5200636.

Jin Z, Sinicrope FA. Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer. Cancers (Basel). 2021 Jan 15;13(2):300. doi: 10.3390/cancers13020300. PMID: 33467526; PMCID: PMC7830023.

Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein PM, Ingle JN, Wolmark N. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005 Oct 20;353(16):1673-84. doi: 10.1056/NEJMoa052122. PMID: 16236738.

Kriege, M., Hollestelle, A., Jager, A. et al. Survival and contralateral breast cancer in CHEK2 1100delC breast cancer patients: impact of adjuvant chemotherapy. Br J Cancer 111, 1004–1013 (2014). https://doi.org/10.1038/bjc.2014.306

BRCA1 and BRCA2 mutation carriers, especially those with breast cancer, face a higher risk of developing a second cancer, including contralateral breast cancer. Individuals with Lynch Syndrome have a significantly increased risk of secondary cancers developing, including colorectal, endometrial, and gastric cancers, also those with TP53 mutations face an increased lifetime risk of multiple cancers, including sarcomas, breast, and brain cancers, often at an early age. 8,9,10

Kathleen E. Malone et al., Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation in BRCA1 or BRCA2. JCO 28, 2404-2410(2010).DOI:10.1200/JCO.2009.24.2495

Win AK, Lindor NM, Winship I, Tucker KM, Buchanan DD, Young JP, Rosty C, Leggett B, Giles GG, Goldblatt J, Macrae FA, Parry S, Kalady MF, Baron JA, Ahnen DJ, Marchand LL, Gallinger S, Haile RW, Newcomb PA, Hopper JL, Jenkins MA. Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. J Natl Cancer Inst. 2013 Feb 20;105(4):274-9. doi: 10.1093/jnci/djs525. Epub 2013 Feb 5. PMID: 23385444; PMCID: PMC3576323.

Bougeard G, Sesboüé R, Baert-Desurmont S, Vasseur S, Martin C, Tinat J, Brugières L, Chompret A, de Paillerets BB, Stoppa-Lyonnet D, Bonaïti-Pellié C, Frébourg T; French LFS working group. Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families. J Med Genet. 2008 Aug;45(8):535-8. doi: 10.1136/jmg.2008.057570. Epub 2008 May 29. PMID: 18511570.

Superior Panel Performance

SNVs - 100% Sensitivity; 99.99% Specificity; PPV >97%

Indels 100% Sensitivity

CNVs97.6% Sensitivity

Variant interpretation based on MANE transcript and in line with ACMG, ACGS, and CanVIG-UK Gene Specific Recommendations, reported as Pathogenic and Likely Pathogenic

Genes are included in Genomics England's Test Directory

Highest Quality Assurance with ISO15189:2022 UKAS accreditation; GENQA participant